FIVE-MEMBERED HETEROCYCLIC COMPOUNDS IN THE TREATMENT OF CHRONIC AND ACUTE PAIN

FIVE-MEMBERED HETEROCYCLIC COMPOUNDS IN THE TREATMENT OF CHRONIC AND ACUTE PAIN

Compounds of formula (I) are found to antagonise N-type calcium channels F(I) wherein R , R and R are organic residues, Y is a linker and R is aryl, heteroaryl, carbocyclyl a heterocyclyl are N-type calcium channel antagonists and are therefore useful in the treatment of both chronic and acute pain....

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Bibliographische Detailangaben
Hauptverfasser: KNUTSEN, LARS, JACOB, STRAY, HOBBS, CHRISTOPHER, JOHN, MELLOR, SARAH, LOUISE, FIUMANA, ANDREA, RADFORD, FLEUR, SMITH, NICHOLA, JANE, EARNSHAW, CHRISTOPHER, GEOFFREY
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of formula (I) are found to antagonise N-type calcium channels F(I) wherein R , R and R are organic residues, Y is a linker and R is aryl, heteroaryl, carbocyclyl a heterocyclyl are N-type calcium channel antagonists and are therefore useful in the treatment of both chronic and acute pain. L'invention concerne des composés de formule (I) ayant pour fonction d'antagoniser les canaux calciques de type N F(I), dans laquelle R , R et R désignent des résidus organiques, Y désigne un liant et R désigne un aryle, hétéroaryle, carbocyclyle et hétérocyclyle qui sont des antagonistes du canal calcique de type N et que l'on utilise, de ce fait dans le traitement de douleurs chroniques et aiguës.