FORMALDEHYDE-AMMONIUM SALT COMPLEXES FOR THE STABILIZATION OF BLOOD CELLS

A stabilization reagent composition, particularly desirable for stabilizing blood samples containing platelets, comprises reactants that generate multiple species of formaldehyde-ammonium complexes; at least one inhibitor of phosphatase enzymatic activity; and at least one inhibitor of protease enzy...

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Bibliographische Detailangaben
1. Verfasser:	MAPLES, JOHN A
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PEST REPELLANTS OR ATTRACTANTS PHYSICS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A stabilization reagent composition, particularly desirable for stabilizing blood samples containing platelets, comprises reactants that generate multiple species of formaldehyde-ammonium complexes; at least one inhibitor of phosphatase enzymatic activity; and at least one inhibitor of protease enzymatic activity. Blood samples and other tissues are stabilized by this composition. Such stabilized samples are produced by methods for stabilizing the tissue by contacting the sample with the composition. Methods for assessing the efficacy of such stabilizing reagents are also included in this invention. La présente invention concerne une composition de réactif qui convient particulièrement pour stabiliser des échantillons de globules contenant des plaquettes. Cette composition comprend des réactifs qui génèrent de multiples espèces de complexes formol-ammonium, au moins un inhibiteur d'activité enzymatique phosphatase et au moins un inhibiteur d'activité enzymatique protéase. On stabilise des échantillons de sang et d'autres tissus avec cette composition. Ces échantillons stabilisés sont produits par des techniques destinées à stabiliser le tissu par une mise en contact de l'échantillon avec cette composition. Cette invention concerne aussi des techniques d'évaluation de l'efficacité de ces réactifs stabilisants.