"1,2,4"OXADIAZOLES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5

The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invent...

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Bibliographische Detailangaben
Hauptverfasser:	XIN, TAO, STEFANAC, TOMISLAV, ISAAC, METHVIN, OSCARSSON, KARIN, YNGVE, ULRIKA, JOHANSSON, MARTIN, SLASSI, ABDELMALIK, EDWARDS, LOUISE, MALMBERG, JOHAN, KERS, ANNIKA, OSTERWALL, CHRISTOFFER, WENSBO, DAVID, STORMANN, THOMAS, M, ARORA, JALAJ, WALDMAN, MANGUS, MCLEOD, DONALD, A, GYBACK, HELENA, MINIDIS, ALEXANDER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to new compounds of formula (I), a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. In particular, there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders. La présente invention se rapporte à de nouveaux composés représentés par la formule (I), à leur procédé de préparation et à de nouveaux intermédiaires préparés par ledit procédé, ainsi qu'à des préparations pharmaceutiques contenant lesdits composés et à l'utilisation thérapeutique de ces derniers.