CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME (BACE) MUTANTS AND USES THEREOF

The present application discloses and claims mutant BACE proteins, recombinant BACE proteins, processes for crystallizing BACE and in particular to its crystal structure and to the uses of this structure in drug discovery. La présente invention concerne des protéines BACE mutantes, des protéines BAC...

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Bibliographische Detailangaben
Hauptverfasser:	SHAH, ALEEM, VUILLARD, LAURENT, MICHEL, MARIE, CLEASBY, ANNE, YON, JEFFREY, ROLAND, HAMILTON, BRUCE, JOHN, PATEL, SAHIL, JOE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present application discloses and claims mutant BACE proteins, recombinant BACE proteins, processes for crystallizing BACE and in particular to its crystal structure and to the uses of this structure in drug discovery. La présente invention concerne des protéines BACE mutantes, des protéines BACE recombinantes, des procédés de cristallisation de l'enzyme BACE, notamment, sa structure cristalline, et les utilisations de cette structure dans la découverte de médicaments.