PROTEIN COMPLEXES OF CELLULAR NETWORKS UNDERLYING THE DEVELOPMENT OF CANCER AND OTHER DISEASES

The present invention relates to protein complexes involved in cellular processes which have been shown to be critical for the development of various forms of cancer, component proteins of the said complexes, fragments and derivatives of the component proteins, and antibodies specific to the complex...

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Hauptverfasser: CRUCIAT, CRISTINA, KRUSE, ULRICH, DREWES, GERARD, MARZIOCH, MARTINA, HELFTENBEIN, GERD, SUPERTI-FURGA, GIULIO, EBERHARD, DIRK, RUFFNER, HEINZ, BAUER, ANDREAS, BOUWMEESTER, TEWIS, MERINO, ALEJANDRO, HOBSON, SCOTT
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention relates to protein complexes involved in cellular processes which have been shown to be critical for the development of various forms of cancer, component proteins of the said complexes, fragments and derivatives of the component proteins, and antibodies specific to the complexes. The present invention also relates to methods for use of the complexes and their interacting proteins in, inter alia, screening, diagnosis, and therapy, as well as to methods of preparing the complexes. La présente invention concerne des complexes protéiniques qui entrent en jeu dans des processus cellulaires qui se sont avérés critiques pour le développement de diverses formes de cancer, des protéines composant de ces complexes, des fragments et des dérivés de ces protéines composant et, des anticorps spécifiques de ces complexes. Cette invention concerne aussi des techniques d'utilisation de ces complexes et leur protéines d'interaction dans la recherche, le diagnostic et la thérapie, entre autres domaines d'utilisation, ainsi que des techniques de préparation de ces complexes.