BENZAMIDE OR PHENYLACETAMIDE DERIVATIVES USEFUL AS THYROID RECEPTOR LIGANDS

This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	ERICSSON, THOMAS, ANDERS, WILSON, MALM, LARS, JOHAN, GADIM, MAHMOUD, RAHIMI, RYONO, DENIS, EVAN, GARG, NEERAJ
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention relates to novel compounds, which are thyroid receptor ligands, and to methods of preparing such compounds. In addition, a method is provided for preventing, inhibiting or treating diseases or disorders associated with metabolism dysfunction or which are dependent upon the expression of a T3 regulated gene, wherein a compound as described herein is administered in a therapeutically effective amount. La présente invention concerne de nouveaux composés, qui sont des ligands de récepteurs de la thyroïde et des techniques de préparation de ces composés. Cette invention concerne aussi une technique de prévention, d'inhibition ou de traitement de maladies ou de pathologies associées à un dysfonctionnement du métabolisme ou dépendantes de l'expression d'un gène régulé T3, un composé de cette invention étant administré en quantité thérapeutiquement efficace.