STABILIZATION OF THE PROFILE OF RELEASE OF ACTIVE SUBSTANCES FROM A FORMULATION

The invention discloses a method of a physical pre-treatment of an active substance, which modifies technologically important physical properties of the active substance so as to enable the manufacture of a formulation having a more stable release profile of the active substance over the whole shelf...

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Bibliographische Detailangaben
Hauptverfasser:	HUMAR, VLASTA, FERCEJ TEMELJOTOV, DARJA, RESMAN, ALEKSANDER, OPRESNIK, MARKO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses a method of a physical pre-treatment of an active substance, which modifies technologically important physical properties of the active substance so as to enable the manufacture of a formulation having a more stable release profile of the active substance over the whole shelf life of the medicine than the profile would be with the same composition, but without pre-treatment. Procédé de pré-traitement physique d'une substance active, qui modifie des propriétés physiques technologiquement importantes de la substance active de manière à permettre la production d'une composition présentant un profil de libération plus stable de la substance active sur toute la durée de conservation du médicament que ce que ce profil aurait été pour la même composition, mais sans pré-traitement.