METHOD OF SELECTING TARGETS FOR GENE SILENCING BY RNA INTERFERENCE

The invention relates to the selection of target regions of RNA transcripts for specific down-regulation of gene expression by RNA interference. Target regions of the transcript are identified on the basis of hybridisation to scanning arrays of antisense oligonucleotides and siRNA reagents comprisin...

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Bibliographische Detailangaben
Hauptverfasser:	SOHAIL, MUHAMMAD, MACAULAY, VALENTINE, MOYA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the selection of target regions of RNA transcripts for specific down-regulation of gene expression by RNA interference. Target regions of the transcript are identified on the basis of hybridisation to scanning arrays of antisense oligonucleotides and siRNA reagents comprising double-stranded RNAs corresponding to the target regions are then synthesised. L'invention concerne la sélection de régions cibles de transcripts d'ARN pour la régulation descendante spécifique de l'expression génique par interférence d'ARN. Des régions cibles du transcript sont identifiées sur la base de l'hybridation sur réseaux scanneurs d'oligonucléotides anti-sens, et des réactifs ARNsi comprenant des ARN à double brin correspondant aux régions cibles sont alors synthétisés.