METHOD FOR BIOEQUIVALENCE DETERMINATION USING EXPRESSION PROFILING

The present invention provides methods to use expression profiles to determine the bioequivalence of two or more pharmaceutically equivalent drug formulations. In addition, this invention provides methods to select drug formulations that are able to substitute for standard drug formulations without...

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Bibliographische Detailangaben
Hauptverfasser:	DRESSMAN, MARLENE, MICHELLE, LAVEDAN, CHRISTIAN, NICOLAS, MC LEAN, LEE, ANNE, POLYMEROPOULOS, MIHAEL, HRISTOS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CALCULATING CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPUTING CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CONTROLLING COUNTING ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PEST REPELLANTS OR ATTRACTANTS PHYSICS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROCESSES OF PREPARING SUCH COMPOSITIONS REGULATING SPIRITS SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides methods to use expression profiles to determine the bioequivalence of two or more pharmaceutically equivalent drug formulations. In addition, this invention provides methods to select drug formulations that are able to substitute for standard drug formulations without change in clinical efficacy. In other embodiments this invention provides computer systems, kits and databases for carrying out the methods of the invention. L'invention concerne des méthodes d'utilisation de profils d'expression pour déterminer la bioéquivalence de deux ou de plusieurs formulations médicamenteuses pharmaceutiquement équivalentes. En outre, l'invention concerne des méthodes permettant de sélectionner des formulations médicamenteuses pouvant se substituer à des formulations médicamenteuses standards, sans changement au niveau de leur efficacité clinique. Dans d'autres modes de réalisation, l'invention concerne des systèmes informatiques, des trousses et des bases de données permettant de mettre en oeuvre les méthodes de l'invention.