ATTENUATED GRAM NEGATIVE BACTERIA

Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid s...

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Bibliographische Detailangaben
Hauptverfasser:	LEGROS, FRANCOIS-XAVIER, FELDMAN, ROBERT, GRAHAM, CROOKE, HELEN, RACHEL, SHEA, JACQUELINE, ELIZABETH, COUTEBROZE, SYLVAIN, GABRIEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed. L'invention concerne un mutant d'une bactérie gram négative, cette bactérie possédant au moins une mutation dans une séquence nucléotidique codant un polypeptide d'une identité supérieure ou égale à 70 %, 75 %, 80 %, 85 %, 90 %, 95 %, 96 %, 97 %, 98 %, ou 99 % avec une séquence d'acides aminés codée par une séquence nucléotidique choisie dans le groupe comprenant les séquences nucléotidiques appelées SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93. Cette mutation a pour résultat une virulence atténuée de la bactérie. L'invention concerne également des compositions immunogènes ainsi que des vaccins contenant un tel mutant.