THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polyn...

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Bibliographische Detailangaben
Hauptverfasser: CASMAN, STACIE, J, BURGESS, CATHERINE, E, ALSOBROOK, JOHN, P. II, BOLDOG, FERENC, L, BENTO, PATRICIA
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins. L'invention concerne des séquences d'acides nucléiques codant pour des nouveaux polypeptides. L'invention concerne également des polypeptides codés par ces séquences d'acides nucléiques, des anticorps se liant de manière immunospécifique au polypeptide, ainsi que des dérivés, des variants, des mutants ou des fragments du nouveau polypeptide, du nouveau polynucléotide ou du nouvel anticorps spécifique au polypeptide. L'invention se rapporte en outre à des vecteurs, des cellules hôtes, des anticorps et des méthodes de recombinaison permettant de diagnostiquer, traiter et prévenir des troubles impliquant l'un quelconque de ces nouveaux acides nucléiques et l'une quelconque de ces nouvelles protéines.