COMPOSITIONS COMPRISING MMP7 MODULATORS FOR THE TREATMENT OF CHRONIC PAIN

The invention discloses MMP7 as a suitable target for the development of new therapeutics to treat or ameliorate chronic pain. The invention relates to methods to treat and/or ameliorate chronic pain and pharmaceutical compositions therefor comprising modulators with inhibitory effect on MMP7 enzyme...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	FOX, ALYSON, BUXTON, FRANCIS, PAUL, GANJU, PAMPOSH, GRAY, ANDREW, J, URBAN, LASZLO, SONG, CHUANZHENG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention discloses MMP7 as a suitable target for the development of new therapeutics to treat or ameliorate chronic pain. The invention relates to methods to treat and/or ameliorate chronic pain and pharmaceutical compositions therefor comprising modulators with inhibitory effect on MMP7 enzyme activity and/or MMP7 gene expression. The invention also relates to a method to identify compounds with therapeutic usefulness to treat chronic pain, comprising identifying compounds that can inhibit MMP7 activity and/or gene expression which can also reverse the pathological effects of chronic pain in vivo. Cette invention a trait à la métalloprotéinase matricielle 7 (MMP7) comme cible adaptée aux fins de la mise au point de nouvelles thérapeutiques ou pour soigner ou atténuer des douleurs chroniques. L'invention porte également sur des méthodes de traitement et/ou d'amélioration de douleurs chroniques ainsi que sur des compositions pharmaceutiques à cet effet, contenant des modulateurs ayant une action inhibitrice de l'activité enzymatique de MMP7 et/ou de l'expression génique de MMP7. L'invention concerne, en outre, une méthode d'identification de composés à destination utilitaire thérapeutique permettant de traiter des douleurs chroniques, laquelle méthode consiste à identifier des composés en mesure d'inhiber l'activité de MMP7 et/ou son expression génique et pouvant également inverser les effets pathologiques des douleurs chroniques in vivo.