DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NEUROPEPTIDE FF RECEPTOR 1 (NPFF1)

The invention provides a human NPFF1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also provides assays for the identificat...

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Bibliographische Detailangaben
Hauptverfasser:	GOLZ, STEFAN, BRUEGGEMEIER, ULF, WEINGAERTNER, BERNHARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a human NPFF1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, respiratory diseases like COPD and asthma and genito-urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of NPFF1 as well as pharmaceutical compositions comprising such compounds. L'invention concerne un NPFF1 humain associé aux maladies hématologiques, aux maladies cardio-vasculaires, aux troubles du système nerveux central et périphérique, aux maladies respiratoires, telles que la BPCO et l'asthme, et aux troubles génito-urinaires. L'invention concerne en outre des méthodes permettant d'identifier des composés utiles pour traiter ou prévenir des maladies hématologiques, des maladies cardio-vasculaires, des troubles du système nerveux central et périphérique, des maladies respiratoires, telles que la BPCO et l'asthme, et des troubles génito-urinaires. L'invention concerne par ailleurs des composés qui se lient au NPFF1 et/ou activent ou inhibent son activité, ainsi que des compositions pharmaceutiques comprenant ces composés.