COMPOSITIONS AND METHODS FOR INHIBITION OF PHOSPHOLIPASE A2 MEDIATED INFLAMMATION

Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provid...

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Hauptverfasser:	SIX, DAVID, A, LUCAS, KARIN, KILLERMANN, KOKOTOS, GEORGE, YAKSH, TONY, CONSTANTINOU-KOKOTOU, VIOLETTA, DENNIS, EDWARD, SVENSSON, CAMILLA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2 (PLA2) activity are provided. A role for PLA2 activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2 activity is provided. Cette invention concerne des inhibiteurs à base de 2-oxo-amide, spécifiques et très puissants, de l'activité de la phospholipase A2 (PLA2). Le rôle de l'activité de PLA2 étant établi dans les processus inflammatoire à médiation spinale, cette invention concerne une méthodes de traitement de l'hyperalgie et autres états inflammatoires associés à l'activité de PLA2..