ALPHA-SUBSTITUTED ARYLALKYL PHOSPHONATE DERIVATIVES

The present invention relates to novel alpha-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo a, Lpa, apo B, apo B associated lipoproteins low density lipoproteins and very low density lipoproteins and for lowering plasma levels of total cholesterol. La p...

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Bibliographische Detailangaben
Hauptverfasser:	IFE, ROBERT, JOHN, AZOULAY, RAYMOND, ESCHENHOF, HARALD, DIEP, VINH, VAN, NGUYEN, LAN, MONG, PHAN, HIEU, TRUNG, NIESOR, ERIC, JOSEPH, BENTZEN, CRAIG, LEIGH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel alpha-substituted arylalkylphosphonate derivatives and their uses for lowering plasma levels of apo a, Lpa, apo B, apo B associated lipoproteins low density lipoproteins and very low density lipoproteins and for lowering plasma levels of total cholesterol. La présente invention a trait à de nouveaux dérivés d'arylalkylphosphonate alpha -substitués et leurs utilisations pour la réduction de concentrations plasmiques de lipoprotéines associées à l'apo (a), Lp(a), apo B, apo B (lipoprotéines de basse densité et lipoprotéines de très basse densité) et pour la réduction de concentrations plasmiques de cholestérol total.