ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES

The present invention relates to novel alpha-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total chole...

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Bibliographische Detailangaben
Hauptverfasser:	IFE, ROBERT, JOHN, AZOULAY, RAYMOND, DIEP, VINH, VAN, NGUYEN, LAN, MONG, PHAN, HIEU, TRUNG, NIESOR, ERIC, JOSEPH, BENTZEN, CRAIG, LEIGH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel alpha-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol. L'invention porte sur des dérivés alpha-substitués d'hétéroarylalkyl phosphonate et leurs utilisations pour abaisser la concentration plasmique en lipoprotéines apo (a), Lp(a), apo B, et associées à apo B (lipoprotéines à basse densité et très basse densité), et abaisser la concentration plasmique en cholestérol total.