AGGRECANASE MOLECULES

Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also di...

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Bibliographische Detailangaben
Hauptverfasser:	DIBLASIO, ELIZABETH, AGOSTINO, MICHAEL, J, COLLINS-RACIE, LISA, A, ZENG, WEILAN, FREEMAN, BETHANY, A, LAVALLIE, EDWARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed. La présente invention concerne de nouvelles protéines d'aggrécanase et les séquences nucléotidiques qui les codent, ainsi que des procédés de production de ces dernières. L'invention se rapporte également à des procédés destinés la mise au point d'inhibiteurs des enzymes de l'aggrécanase et d'anticorps dirigés contre ces enzymes, destinés au traitement d'états caractérisés par la dégradation de l'aggrécane.