MODULATING INSULIN RECEPTOR SIGNALING THROUGH TARGETING FACL

Human FACL genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of FACL, comprising screeing for agents that modulate the activity of FACL are provided. L'invention concerne...

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Hauptverfasser:	O'BRIEN, CAROL, L, KADYK, LISA, C
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Human FACL genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of FACL, comprising screeing for agents that modulate the activity of FACL are provided. L'invention concerne des gènes humains de FACL (acyl-CoA synthétase) identifiés comme des modulateurs de la signalisation des récepteurs de l'insuline (INR), constituant ainsi des cibles thérapeutiques contre les troubles liés à une mauvaise signalisation des récepteurs de l'insuline (INR). L'invention concerne également des méthodes d'identification de modulateurs des gènes de FACL, comprenant le criblage d'agents modulant l'activité de FACL.