CRBs AS MODIFIERS OF BRANCHING MORPHOGENESIS AND METHOD OF USE

The invention concerns genes that modify branching morphogenesis, that is, cellular processes involved in the formation of branched networks. The invention provides methods for utilizing these branching morphogenesis modifier genes and encoded polypeptides to identify agents that modify the function...

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Bibliographische Detailangaben
Hauptverfasser:	DIAGANA, THIERRY, TIDIANE, PLOWMAN, GREGORY, D, KEYES, LINDA, NOLAN, OLLMANN, MICHAEL, MARTIN, MAXWELL, MARK, E, KARIM, FELIX, D
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention concerns genes that modify branching morphogenesis, that is, cellular processes involved in the formation of branched networks. The invention provides methods for utilizing these branching morphogenesis modifier genes and encoded polypeptides to identify agents that modify the function of such genes or polypeptides. Such agents are candidate therapeutic agents for treatment of disorders associated with defective or impaired branching morphogenesis function. In particular embodiments the agents are candidate therapeutic agents for treatment of excessive or impaired angiogenesis. La présente invention concerne des gènes CRB humains qui sont identifiés en tant que modulateurs de la morphogenèse ramifiée et qui, de ce fait, sont des cibles thérapeutiques pour troubles liés à une fonction défectueuse de la morphogenèse ramifiée. Cette invention a également trait à des méthodes d'identification de modulateurs de la morphogenèse ramifiée consistant à cribler des agents qui modulent l'activité de CRB.