MEDICAL DEVICES HAVING ANTIMICROBIAL COATINGS THEREON

The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula (I) or (II). The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram−positive and Gram−negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended−wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon. The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial coating including at least one layer of polyquat of formula I or II. The antimicrobial coating on the medical device of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial, a low toxicity, low coefficient of friction, and increased hydrophilicity while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial coating thereon. L'invention concerne un dispositif médical, de préférence une lentille de contact, qui comporte un revêtement antimicrobien constitué d'au moins une couche de polyquat de formule (I) ou (II). Le revêtement antimicrobien sur le dispositif médical de l'invention présente une efficacité antimicrobienne élevée contre les micro-organismes, dont les bactéries à Gram positif et Gram négatif, une faible toxicité, un faible coefficient de frottement, et une hydrophilicité accrue tout en conservant ses propriétés générales recherchées, telles que la perméabilité à l'oxygène et la perméabilité aux ions de la matière constitutive de la lentille. De plus, l'invention porte sur un procédé de fabrication d'un dispositif médical, de préférence une lentille de contact, dotée d'un revêtement antimicrobien.