THE FUNCTIONAL ROLE AND POTENTIAL THERAPEUTIC USE OF REELIN, GAS6 AND PROTEIN S IN RELATION TO ADULT NEURAL STEM OR PROGENITOR CELLS

The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to reagent that modulates the proliferation, migr...

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Hauptverfasser:	KORTESMAA, JARKKO, LUNDH, HANNA, PATRONE, CESARE, BERTILSSON, GORAN, LINDQUIST, PER, MERCER, ALEX, MCGUIRE, JACCQUELINE, ZACHRISSON, OLOF, FRISEN, JONAS, HELLSTROM, KRISTINA, RONNHOLM, HARRIET, WIKSTROM, LILIAN, HEIDRICH, JESSICA, FALK, ANNA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells via Reelin, Gas6 or Protein S signaling. These methods are useful for reducing at least one symptom of the disorder. L'invention concerne de manière générale des procédés destinés à influencer des cellules du système nerveux central afin d'obtenir une descendance utile dans le traitement des troubles du SNC. Plus particulièrement, l'invention comprend des procédés destinés à exposer un patient souffrant dudit trouble à un réactif qui module la prolifération, la migration, la différentiation et la survie des cellules du système nerveux central par l'intermédiaire d'une signalisation de protéines Reelin, Gas6 ou S. Ces procédés sont utiles pour réduire au moins un symptôme dudit trouble.