METHOD OF SCREENING FOR DRUG HYPERSENSITIVITY REACTION

Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFa gene, the class 1 HLA genes, or a combination of both the TNF alpha and HLA genes....

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Bibliographische Detailangaben
Hauptverfasser:	HUGHES, ARLENE, R, HETHERINGTON, SETH, MOSTELLER, JR., MICHAEL, SHORTINO, DENISE, D, LAI, ERIC, H
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFa gene, the class 1 HLA genes, or a combination of both the TNF alpha and HLA genes. L'invention concerne des procédés permettant d'évaluer le risque de signes cliniques d'hypersensibilité à des composés de nucléosides antiviraux, notamment à l'abacavir. Ces procédés consistent à effectuer un génotypage des sujets afin de rechercher des polymorphismes dans le gène du TNF alpha , dans les gènes HLA de la classe 1 ou dans une combinaison des gènes du TNF alpha et des gènes HLA.