G PROTEIN-COUPLED RECEPTOR ASSAY

The present invention relates to novel methods and compositions for the diagnosis, treatment and prognosis of G-protein coupled receptor (GPCR)-related disorders through inhibition of regulators of G-protein signaling (RGS) proteins. The present invention relates to methods of screening and assessin...

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Bibliographische Detailangaben
Hauptverfasser:	YOUNG, KATHLEEN, HART, HO, GUYU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to novel methods and compositions for the diagnosis, treatment and prognosis of G-protein coupled receptor (GPCR)-related disorders through inhibition of regulators of G-protein signaling (RGS) proteins. The present invention relates to methods of screening and assessing test compounds useful in the intervention and prevention of GPCR-related disorders including neuropsychiatric and cardiopulmonary disorders. The invention further relates to methods to identify inhibitors for RGS expression or activity which are useful in the modulation of GPCR signaling pathways. La présente invention concerne des procédés et des compositions visant à diagnostiquer, traiter et pronostiquer des troubles en relation avec les récepteurs couplés aux protéines G ou "GPCR" par inhibition des régulateurs des protéines de signalisation des protéines G ou "RGS". L'invention concerne également des procédés pour la recherche systématique et la vérification de composés test convenant pour le traitement et la prévention des troubles en relation avec les GPCR, et notamment des troubles neuropsychiatriques et cardio-pulmonaires. L'invention concerne enfin des procédés visant à l'identification d'inhibiteurs d'expression ou d'activité des RGS et convenant à la modulation des chemins de signalisation des GPCR.