METHODS FOR GENETIC MODIFICATION OF HEMATOPOIETIC PROGENITOR CELLS AND USES OF THE MODIFIED CELLS

Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The inv...

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Bibliographische Detailangaben
Hauptverfasser:	SYMONDS, GEOFFERY, P, SUN, LUN-QUAN, MACPHERSON, JANET, FANNING, GREG, AMADO, RAFAEL, GERLACH, WAYNE
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection. L'invention porte sur des compositions et sur des procédés relatifs à la thérapie génique et s'appliquant notamment aux cellules progénitrices hématopoïétiques, à des cellules de transduction et à leur procédé de production et à des procédés utilisant ces cellules pour obtenir une prise de greffe prolongée des cellules hématopoïétiques modifiées chez l'homme. L'invention porte notamment sur la thérapie génique ex vivo des cellules hématopoïétiques s'utilisant dans le traitement ou la prévention de l'infection par le VIH.