MULTIVALENT MYCOPLASMA BACTERIN

The present invention provides a bacterin comprising at least two virulent Mycoplasma bovis isolates of differing biotypes, in an amount sufficient to immunize a calf or cow against infection by Mycoplasma bovis , an adjuvant, and a pharmaceutically acceptable carrier. Further provided is a method of producing the bacterin of the present invention. Finally, the present invention also provides a method of immunizing a calf or cow against Mycoplasma bovis infection, especially infection associated with BRD, compris ing administering to the calf or cow a dose of a bacterin made according to the present invention in an amount effective to elicit a protective response in the animal, as evidenced by a decrease in the mortality and morbidity associated with natural infection. The present invention provides a bacterin comprising at least two virulent Mycoplasma bovis isolates of differing biotypes, in an amount sufficient to immunize a calf or cow against infection by Mycoplasma bovis, an adjuvant, and a pharmaceutically acceptable carrier. Further provided is a method of producing the bacterin of the present invention. Finally, the present invention also provides a method of immunizing a calf or cow against Mycoplasma bovis infection, especially infection associated with BRD, compris ing administering to the calf or cow a dose of a bacterin made according to the present invention in an amount effective to elicit a protective response in the animal, as evidenced by a decrease in the mortality and morbidity associated with natural infection. L'invention concerne un vaccin antimicrobien comprenant, au moins, deux isolats virulents de Mycoplasma bovis de biotypes différents, en quantité suffisante pour permettre l'immunisation d'un veau ou d'un vache contre l'infection par Mycoplasma bovis, un adjuvant et un support acceptable sur le plan pharmaceutique. L'invention concerne, en outre, un procédé de production du vaccin antimicrobien. Elle concerne aussi une méthode d'immunisation d'un veau ou d'une vache contre une infection par Mycoplasma bovis, plus spécialement une infection associée à la grippe bovine, consistant à administrer au veau ou à la vache une dose du vaccin antimicrobien de l'invention en une quantité permettant de provoquer une réponse protectrice chez l'animal, comme le montrent les diminutions de mortalité et de morbidité associées à une infection naturelle.