COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS

Compounds and pharmaceutical compositions useful as anti-parasitic agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibit...

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Bibliographische Detailangaben
Hauptverfasser:	ARALDI, GIAN, L, GOLDMAN, ERICK, A, LIM-WILBY, MARGUERITA, WEINHOUSE, MICHAEL, I, SEMPLE, JOSEPH, EDWARD
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds and pharmaceutical compositions useful as anti-parasitic agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided. L'invention concerne des composés et des compositions pharmaceutiques utiles comme agents anti-parasitaires, notamment dans le traitement, la prévention ou l'amélioration d'au moins un symptôme du paludisme ou de la maladie de Chaga. L'invention concerne plus précisément des procédés de modulation de l'activité du falcipain ou du cruzain et, de préférence, d'inhibition du falcipain ou du cruzain, par lesdits composés et compositions.