ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO
Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (I) wherein R1 through R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that...
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Zusammenfassung: | Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (I) wherein R1 through R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to inhibition of the JNK pathway. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
La présente invention concerne des composés qui possèdent une activité inhibitrice du chemin JNK. Ces composés sont des dérivés d'anilinopyrimidine qui présentent la structure suivante: (I). Dans cette structure les R1, ,R6 sont tels que définis dans les spécifications. Ces composés conviennent pour le traitement d'une grande plage de pathologies sensibles à l'inhibition du chemin JNK. Cette invention concerne aussi des techniques de traitement de ces pathologies, de même que des compositions pharmaceutiques contenant un ou plusieurs composés parmi ceux qui sont présentés dans cette invention. |
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