AGGRECANASE MOLECULES

Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclos...

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Bibliographische Detailangaben
Hauptverfasser:	AGOSTINO, MICHAEL, JOHN, TWINE, NATALIE, CONSTANCE, RACIE, LISA, ANNE, MORRIS, ELISABETH, ANN, WOLFMAN, NEIL, MICHAEL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed. L'invention concerne des protéines d'aggrécanase et les séquences nucléotidiques les codant, ainsi que des procédés de production desdites protéines. L'invention concerne également des procédés destinés à développer des inhibiteurs des enzymes d'aggrécanase et des anticorps aux enzymes pour le traitement de conditions caractérisées par la dégradation d'aggrecan.