TRANSGENIC DROSOPHILA MELANOGASTER EXPRESSING BETA AMYLOID

Transgenic files displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these files in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease,...

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Bibliographische Detailangaben
Hauptverfasser:	REINHARDT, MISCHA, WERNER, HENRI, MARIE, KONSOLAKI, MARY, FREULER, FELIX, DENGLER, UWE, JOCHEN, ZUSMAN, SUSAN, COHEN, DALIA, FINELLI, ALYCE, LYNN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Transgenic files displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these files in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed. L'invention concerne des mouches transgéniques présentant des phénotypes modifiés en raison de l'expression de la protéine bêta-amyloïde et des parties C99 du gène humain APP. L'utilisation de ces mouches dans un procédé d'identification de gènes de Drosophila et les homologues humains de ces gènes, qui sont potentiellement impliqués dans la maladie d'Alzheimer. L'utilisation de ces homologues humains en tant que cibles médicamenteuses destinées au développement de thérapies de traitement de la maladie d'Alzheimer et d'autres états associés aux défauts dans la voie de protéine précurseur amyloïde, ainsi qu'en tant que compositions pharmaceutiques comprenant des substances destinées à ces gènes.