THROMBIN INHIBITORS

THROMBIN INHIBITORS

Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: where R is hydrogen, or C1-4 alkyl, (CH2)0-1CN, C(O)R , (CH2)0-1CO2R , CF3, OR , halogen, SR , S(O)R , S(O)2R , NR R . L'invention concerne...

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Bibliographische Detailangaben
Hauptverfasser: ISAACS, RICHARD, C, STAAS, DONNETTE, D, SAVAGE, KELLY, L, LYLE, TERRY, A, WILLIAMS, PETER, D
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds of the invention are useful in inhibiting thrombin and treating blood coagulation and cardiovascular disorders and have the following structure: where R is hydrogen, or C1-4 alkyl, (CH2)0-1CN, C(O)R , (CH2)0-1CO2R , CF3, OR , halogen, SR , S(O)R , S(O)2R , NR R . L'invention concerne des composés pouvant inhiber la thrombine et traiter la coagulation sanguine et les troubles cardiovasculaires. Ces composés présentent la structure suivante dans laquelle R est hydrogène ou alkyle C1-4, (CH2)0-1CN, C(O)R , (CH2)0-1CO2R , CF3, OR , halogène, SR , S(O)R , S(O)2R , NR R .