IDENTIFICATION OF NEW THERAPEUTIC TARGETS FOR MODULATING BILE ACID SYNTHESIS

Methods for identifying compounds that modulate bile acid synthesis by assessing their ability to act as ligands for short heterodimerizing partner-1 or liver receptor homologue-1 are provided. Also provided are compositions containing these ligands as well as methods for administering these composi...

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Bibliographische Detailangaben
Hauptverfasser:	JONES, STACEY, ANN, MALONEY, PATRICK, REED, GOODWIN, BRYAN, JAMES, KLIEWER, STEVEN, ANTHONY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
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Zusammenfassung:	Methods for identifying compounds that modulate bile acid synthesis by assessing their ability to act as ligands for short heterodimerizing partner-1 or liver receptor homologue-1 are provided. Also provided are compositions containing these ligands as well as methods for administering these compositions to modulate bile acid synthesis and cholesterol and lipid homeostasis. L'invention concerne des procédés pour identifier les composés qui modulent la synthèse des acides biliaires par l'estimation de leur capacité d'agir en tant que ligands pour un partenaire-1 court de formation d'hétérodimères ou un homologue-1 de récepteurs du foie. Elle concerne aussi des compositions contenant ces ligands ainsi que des procédés pour administrer ces compositions pour moduler la synthèse des acides biliaires et l'homéostasie des lipides et du cholestérol.