IMPROVED VIRUS LIKE PARTICLES BASED ON SMALL ENVELOPE PROTEIN FROM HEPATITIS B (HBsAg-S)

Isolated polynucleotides comprising a HBsAg-S coding sequence that is adapted to receive an insert coding sequence, within a part of the HBsAg-S coding sequence that encodes an exposed site within the external loop of HBsAg-S, and still encode a HBsAg-S that is able to assemble into a VLP. Proteins...

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Bibliographische Detailangaben
Hauptverfasser:	MACNAUGHTON, THOMAS,BERNARD, GOWANS, ERIC,JAMES, NETTER, HANS,JURGEN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Isolated polynucleotides comprising a HBsAg-S coding sequence that is adapted to receive an insert coding sequence, within a part of the HBsAg-S coding sequence that encodes an exposed site within the external loop of HBsAg-S, and still encode a HBsAg-S that is able to assemble into a VLP. Proteins encoded by the polynucleotides, recombinant VLPs and various uses thereof are also described. L'invention concerne des polynucléotides isolés comprenant une séquence codante de AgHB-S pouvant recevoir une séquence codante introduite, dans une portion de la séquence codante de AgHBS codant pour un site exposé à l'intérieur de la boucle extérieure de AgHBS, et codant également pour un AgHBS pouvant se regrouper en une particule de type virus . L'invention concerne également des protéines codées par les polynucléotides, des particules de type virus de recombinaison, ainsi que diverses utilisations de ceux-ci.