PROCESS FOR THE SYNTHESIS OF OXANDROLONE

PROCESS FOR THE SYNTHESIS OF OXANDROLONE

A process is disclosed for synthesizing oxandrolone 1 involving the bromination of compound 2 to obtain compound 3, followed by the highly selective de-bromination of compound 3 to obtain compound 4, followed by the oxidation of compound 4 to obtain compound 6, and finally the reduction of compound...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZIZELMAN, PAUL, M, CABAJ, JOHN, E, KAIRYS, DAVID, L
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:A process is disclosed for synthesizing oxandrolone 1 involving the bromination of compound 2 to obtain compound 3, followed by the highly selective de-bromination of compound 3 to obtain compound 4, followed by the oxidation of compound 4 to obtain compound 6, and finally the reduction of compound 6 to obtain oxandrolone 1. La présente invention concerne un procédé de synthèse d'oxandrolone (1) comportant la bromuration du composé (2) pour obtenir le composé (3), suivie d'une dé-bromuration hautement sélective du composé (3) pour obtenir le composé (4), suivie d'une oxydation du composé (4) pour obtenir le composé (6), et enfin la réduction du composé (6) pour l'obtention d'oxandrolone.