METHODS AND REAGENTS FOR IDENTIFYING INSULIN RESPONSE MODULATORS AND THERAPEUTIC USES THEREFOR

Methods of identifying insulin response modulators are provided. In particular, methods that feature identifying modulators of insulin-responsive aminopeptidase (IRAP) and insulin-degrading enzyme (IDE), or activities associated therewith, are provided. Therapeutic methods utilizing compounds identi...

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Bibliographische Detailangaben
1. Verfasser:	BROOKS, CYDNEY, C
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Methods of identifying insulin response modulators are provided. In particular, methods that feature identifying modulators of insulin-responsive aminopeptidase (IRAP) and insulin-degrading enzyme (IDE), or activities associated therewith, are provided. Therapeutic methods utilizing compounds identified according to the methods of the invention are also provided. L'invention concerne des méthodes servant à identifier des modulateurs de la réponse à l'insuline. Elle concerne en particulier des méthodes qui permettent d'identifier des modulateurs de l'aminopeptidase contrôlée par l'insuline (IRAP) et de l'enzyme dégradant l'insuline (IDE), ou d'activités associées à ces enzymes. L'invention concerne également des méthodes thérapeutiques faisant appel aux composés identifiés selon les méthodes de l'invention.