AROMATIC SULFONE HYDROXAMATES AND THEIR USE AS PROTEASE INHIBITORS

This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia , inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity....

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Bibliographische Detailangaben
Hauptverfasser:	VILLAMIL, CLARA, I, TALLEY, JOHN, J, BEDELL, LOUIS, J, BECKER, DANIEL, P, FRESKOS, JOHN, N, BOEHM, TERRI, L, BARTA, THOMAS, E, KOLODZIEJ, STEVE, A, NORTON, MONICA, B, WANG, TIJUAN, JANE, HOCKERMAN, SUSAN L, FOBIAN, YVETTE, M, KASSAB, DARREN, J, MCDONALD, JOSEPH, J, RICO, JOSEPH, G
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia , inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity. La présente invention concerne des sulfone hydroxamates aromatiques (connus également sous le nom d' /= ) et des sels de ces derniers qui, entre autres, inhibent l'activité de la métalloprotéinase matricielle (connue également sous le nom de /= ou /= ) et/ou l'activité de l'agrécanase. L'invention se rapporte également à un procédé de prévention ou de traitement qui consiste à administrer ce composé ou ce sel dans une quantité efficace pour inhiber la MMP et/ou l'agrécanase à un animal, en particulier à un mammifère souffrant (ou susceptible de souffrir) d'un état pathologique associé à l'activité de la MMP et/ou de l'agrécanase.