BSTP-TRANS PROTEIN AND RELATED REAGENTS AND METHODS OF USE THEREOF

The invention provides a protein (BSTP-TRANS) and polynucleotides which identify and encode BSTP-TRANS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. In addition, the invention provides methods for treating or preventing disorders of cell prolifer...

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Bibliographische Detailangaben
Hauptverfasser:	BOTSTEIN, DAVID, ROSS, DOUGLAS, BROWN, PATRICK, O, PEROU, CHUCK, RING, BRIAN, SEITZ, ROB
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides a protein (BSTP-TRANS) and polynucleotides which identify and encode BSTP-TRANS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. In addition, the invention provides methods for treating or preventing disorders of cell proliferation, particularly breast cancer, by administering a pharmaceutical composition comprising a polypeptide, polynucleotide, or antibody of the invention. The invention also provides methods of classifying diseases, particularly breast cancer, by detecting expression of BSTP-TRANS or of a polynucleotide encoding BSTP-TRANS, and methods of providing diagnostic, prognostic, and/or predictive information for a patient based on the detection and/or measurement of BSTP-TRANS or of a gene that encodes BSTP-TRANS or of a mutation in the BST-TRANS gene. Cette invention concerne une protéine (BSTP-TRANS) et des polynucléotides qui identifient et codent BSTP-TRANS. Elle concerne des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes, ainsi que des méthodes de traitement ou de prévention de troubles liés à la prolifération de cellules, notamment le cancer du sein, par administration d'une composition pharmaceutique contenant un polypeptide, un polynucléotide ou un anticorps de l'invention. L'invention concerne en outre des méthodes de classification de maladies, notamment le cancer du sein, par détection de l'expression de BSTP-TRANS ou d'un polynucléotide codant BSTP-TRANS, et des méthodes de fourniture de données diagnostiques, pronostiques et/ou prédictives pour un patient, fondées sur la détection et/ou la mesure de BSTP-TRANS ou d'un gène codant BSTP-TRANS, ou d'une mutation dans le gène BST-TRANS.