NOVEL SIGNALLING POLYPEPTIDE

The present invention provides a novel signalling polypeptide that represents the first example of a signalling intermediate directly linking the MAP kinase signalling pathway to its downstream transcription factor targets. The invention further provides a binding polypeptide that is capable of bind...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BAKER, DAVID, ISH-HOROWICZ, DAVID, MILLE-BAKER, BLANDINE, DIBB, NICHOLAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides a novel signalling polypeptide that represents the first example of a signalling intermediate directly linking the MAP kinase signalling pathway to its downstream transcription factor targets. The invention further provides a binding polypeptide that is capable of binding to the polypeptide, methods of diagnosis and treatment of diseases and pharmaceutical compositions. Methods of identifying compounds that modulate the activity of the polypeptide are also provided. Cette invention porte sur un nouveau polypeptide de signalisation qui constitue le premier exemple d'un intermédiaire de signalisation liant directement la voie de signalisation de kinase MAP à ses cibles de facteur de transcription en aval. Cette invention concerne également un polypeptide de liaison pouvant se lier au polypeptide, des méthodes de diagnostic et de traitement de maladies ainsi que des compositions pharmaceutiques. La présente invention concerne également des méthodes d'identification de composés qui modulent l'activité du polypeptide.