NOVEL MHC MOLECULE CONSTRUCTS, AND METHODS OF EMPLOYING THESE CONSTRUCTS FOR DIAGNOSIS AND THERAPY, AND USES OF MHC MOLECULES

Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target c...

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Bibliographische Detailangaben
Hauptverfasser:	SCHOELLER, JOERGEN, AAMELLEM, OEYSTEIN, PETERSEN, LARS, OESTERGAARD, WINTHER, LARS, BUUS, SOEREN, RUUB, ERIK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as in various methods. In particular, novel MHC molecule constructs comprising one or more MHC molecules are disclosed. The affinity and avidity of the MHC molecules of the constructs are surprisingly high. The possibility of presenting to the target cells a plurality of MHC molecules makes the MHC molecule constructs an extremely powerful tool e.g. in the field of diagnosis. The invention relates in general to the field of therapy, including therapeutic methods and therapeutic compositions. Also comprised by the present invention is the sample-mounted use of MHC molecules, MHC molecule multimers, and MHC molecule constructs. L'invention concerne de nouveaux composés porteurs de ligands pouvant se lier à des contre-récepteurs sur des cellules cibles appropriées. Ces composés possèdent de nombreux avantages qui permettent de les utiliser dans diverses applications, notamment en tant que systèmes de détection, pour la détection de cellules cibles appropriées, ainsi que dans diverses méthodes. L'invention concerne en particulier de nouvelles constructions de molécules MHC comprenant une ou plusieurs molécules MHC. L'affinité et l'avidité des molécules MHC de ces constructions sont étonnamment élevées. La possibilité de présenter aux cellules cibles une pluralité de molécules MHC fait de ces constructions de molécules MHC un outil extrêmement puissant, p. ex. en matière de diagnostic. L'invention concerne en général le domaine de la thérapie, et notamment des méthodes et des compositions thérapeutiques. La présente invention concerne par ailleurs l'utilisation sur échantillon de molécules MHC, de multimères de molécules MHC et de constructions de molécules MHC.