VIRAL REPORTER PARTICLES

The present invention features a chimeric protein containing a beta-lactamase region and either a Vpr region or a Vpx region. The chimeric protein can be packaged into a viral reporter particle, introduced into a cell recognized by the viral particle and provide intracellular beta-lactamase activity...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	MILLER, MICHAEL, D, SIMON, ADAM, J, HAZUDA, DARIA, J, LINEBERGER, JANET, E
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention features a chimeric protein containing a beta-lactamase region and either a Vpr region or a Vpx region. The chimeric protein can be packaged into a viral reporter particle, introduced into a cell recognized by the viral particle and provide intracellular beta-lactamase activity. The present invention features a chimeric protein containing a -lactamase region and either a Vpr region or a Vpx region. The chimeric protein can be packaged into a viral reporter particle, introduced into a cell recognized by the viral particle and provide intracellular -lactamase activity. La présente invention concerne une protéine chimérique contenant une région -lactamase et une région Vpr ou une région Vpx. Cette protéine chimérique peut être intégrée dans une particule rapporteur virale, introduite dans une cellule reconnue par la particule virale, et conférer une activité -lactamase intracellulaire.