CATABOLITE REPRESSION CONTROL (CRC) GENE AND PSEUDOMONAS VIRULENCE

A method of screening for compounds that inhibit the virulence of Pseudomonas bacteria comprises the steps of: providing a culture medium comprising Pseudomonas bacteria; administering a test compound to said bacteria; and then detecting the presence or absence of inhibition of the catabolite repres...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	HAGER, PAUL, W, COLLIER, DAVID, N, PHIBBS, PAUL, V
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A method of screening for compounds that inhibit the virulence of Pseudomonas bacteria comprises the steps of: providing a culture medium comprising Pseudomonas bacteria; administering a test compound to said bacteria; and then detecting the presence or absence of inhibition of the catabolite repression control (Crc) protein in said bacteria, the inhibition of the Crc protein indicating said compound has antivirulence activity against Pseudomonas bacteria. Antivirulence compounds and the use thereof in treating Pseudomonas infections are also disclosed. Une méthode de criblage de composés qui inhibent la virulence des bactéries Pseudomonas consi ste à : prévoir un milieu de culture comprenant des bactéries Pseudomonas ; administrer un co mposé d'essai auxdites bactéries ; et détecter la présence ou l'absence d'inhibition de la protéine de régulation de la répression catabolique (Crc) dans lesdites bactéries, l'inhibition de la protéine Crc indiquant que ledit composé possède une activité antivirulence contre les bactéries Pseudomonas . Les composés antivirulence et leur utili sation dans le traitement d'infections à Pseudomonas sont également décrits.