PROCESS FOR PRODUCTION OF NANOPARTICLES AND MICROPARTICLES BY SPRAY FREEZING INTO LIQUID

The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller...

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Bibliographische Detailangaben
Hauptverfasser:	WILLIAMS, ROBERT, O., III, BARRON, MELISA, K, JOHNSTON, KEITH, P, YU, ZHONGSHUI, ROGERS, TRUE, L, YOUNG, TIMOTHY, J, HU, JIAHUI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BABY COMFORTERS BLASTING CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY COMBINED HEATING AND REFRIGERATION SYSTEMS CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS DRYING DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM HEAT PUMP SYSTEMS HEATING HUMAN NECESSITIES HYGIENE LIGHTING LIQUEFACTION SOLIDIFICATION OF GASES MANUFACTURE OR STORAGE OF ICE MECHANICAL ENGINEERING MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRODUCING, WORKING OR HANDLING ICE REFRIGERATION MACHINES, PLANTS OR SYSTEMS REFRIGERATION OR COOLING SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING WEAPONS
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Beschreibung
Zusammenfassung:	The present invention provides a system and a method for the production of microparticles and nanoparticles of materials that can be dissolved. The system and method of the present invention provide quicker freezing times, which in turn produces a more uniform distribution of particle sizes, smaller particles, particles with increased porosity and a more intimate mixing of the particle components. The system and method of the present invention also produce particles with greater surface area than conventional methods. One form of the present invention provides a method for the preparation of particles. An effective ingredient is mixed with water, one or more solvents, or a combination thereof, and the resulting mixture is sprayed through an insulating nozzle located at or below the level of a cryogenic liquid. The spray generates frozen particles. L'invention concerne un système et un procédé de production de microparticules et de nanoparticules de matières pouvant être dissoutes. Le système et le procédé comportent des temps de congélation plus rapides, ce qui permet d'obtenir une distribution plus uniforme des tailles de particules, des particules plus petites, des particules à porosité accrue et un mélange plus intime des constituants de particules. Le système et le procédé permettent aussi de produire des particules présentant une plus grande surface par rapport à celle de particules obtenues par des procédés classiques. Une forme de l'invention concerne un procédé de préparation de particules. Un ingrédient efficace est mélangé avec de l'eau, un ou plusieurs solvants ou une combinaison de ceux-ci, et le mélange obtenu est pulvérisé par une buse isolante située au niveau ou sous le niveau d'un liquide cryogénique. Cette pulvérisation produit des particules congelées.