POLYMORPHIC FORMS/HYDRATES OF N-[4-(3-CHLORO-4-FLUOROPHENYLAMINO)-7-(3-MORPHOLIN-4-YLPROPOXY)-QUINAZOLIN-6-YL]-ACRYLAMIDE DIHYDROCHLORIDE

POLYMORPHIC FORMS/HYDRATES OF N-[4-(3-CHLORO-4-FLUOROPHENYLAMINO)-7-(3-MORPHOLIN-4-YLPROPOXY)-QUINAZOLIN-6-YL]-ACRYLAMIDE DIHYDROCHLORIDE

There are described polymorphic forms/hydrates of N-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochloride, processes for their preparation, as well as the use of the same for the preparation of medicaments with irreversible tyrosine kinase inhibiti...

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Bibliographische Detailangaben
Hauptverfasser: STEINER, KLAUS, HUELS, DIETMAR, WESTERMAYER, MANFRED, BARTH, HUBERT, SCHNEIDER, SIMON, MUEHLENFELD, ANDREAS
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:There are described polymorphic forms/hydrates of N-[4-(3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochloride, processes for their preparation, as well as the use of the same for the preparation of medicaments with irreversible tyrosine kinase inhibiting action. L'invention concerne des formes polymorphes/hydrates de N-[4-(3-chloro-4-fluorophénylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]-acrylamide dihydrochlorure, des procédés de leur préparation, ainsi que leurs utilisations dans la préparation de médicaments à action inhibitrice irréversible de la tyrosine kinase.