HUMAN CHEMOKINE BETA-10 MUTANT POLYPEPTIDES

Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infectio...

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Hauptverfasser:	OLSEN, HENRIK, S, SALCEDO, THEODORA, ADAMS, MARK, D, PARMELEE, DAVID, APPELBAUM, EDWARD, R, GENTZ, SOLANGE, H., L, LI, YULING, WHITE, JOHN, R, LI, HAODONG, ALDERSON, RALPH
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Human chemokine Beta-10 polypeptides and DNA (RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment of leukemia, tumors, chronic infections, autoimmune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemokine polypeptides and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. L'invention concerne des polypeptides de la chimiokine humaine Beta-10 et un ADN (ARN) codant ces polypeptides de la chimiokine, ainsi qu'un processus destiné à la production de ces polypeptides par techniques de recombinaison génétique. L'invention concerne également des méthodes destinées à l'utilisation de ces polypeptides de la chimiokine dans le traitement de la leucémie, de tumeurs, d'infections chroniques, de la maladie auto-immune, des troubles fibreux, des troubles de cicatrisation et du psoriasis. L'invention concerne également des antagonistes utilisés contre ces polypeptides de la chimiokine et leur utilisation comme éléments thérapeutiques pour traiter la polyarthrite rhumatoïde, les maladies auto-immunes, les maladies inflammatoires chroniques, les maladies infectieuses, les réactions allergiques, les fièvres ne dépendant pas de la prostaglandine et l'aplasie médullaire.