A GLYCOPEPTIDE AND PREPARATION THEREOF

The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl- beta -(1,4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of N-acetylglulosaminyl-N-acet...

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Hauptverfasser:	HORNBACK, WILLIAM, JOSEPH, DINGESS-HAMMOND, ELIZABETH, ANNE, VANNIEUWENHZE, MICHAEL, SCOTT, BLASZCZAK, LARRY, CHRIS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl- beta -(1,4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopeptide is useful for the preparation of N-acetylglulosaminyl-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds having a glucosaminyl- beta -(1,4)-N-acetylmuramic acid disaccharide core. L'invention concerne la synthèse stéréospécifique d'un glycopeptide faisant appel à un schéma de protection triplement orthogonal, et en particulier la synthèse d'un monopeptide de N-acétylglucosaminyl- beta -[1,4]-N-acétylmuramyle et de dérivés de celui-ci . Ce glycopeptide est utile pour la préparation de GMDP et de composés similaires comprenant une partie centrale disaccharide d'acide glucosaminyl- beta -[1,4]-N-acétylmuramique.