NON-SQUAMOUS EPITHELIUM-SPECIFIC TRANSCRIPTION

The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific promoter or functional fragment thereof allowing for expression of a nucleic acid of interest operably link...

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Bibliographische Detailangaben
Hauptverfasser:	VAN DER MOLEN, HENK, TERPSTRA, PETER, RUITERS, MARCEL, HERMAN, JOSEF, MCLAUGHLIN, PAMELA, MARIJKE, JANE, DOKTER, WILLEM, HENDRIK, ABRAHAM, HARMSEN, MARTIN, CONRAD, DE LEIJ, LOU, FRANCISCUS, MARIA, HUBERTUS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the field of cancer therapy and diagnosis, in particular of carcinomas. The invention provides an isolated and/or recombinant nucleic acid comprising a tissue specific promoter or functional fragment thereof allowing for expression of a nucleic acid of interest operably linked to said promoter or functional fragment thereof in a cancer cell wherein said expression in said cancer cell is essentially carcinoma selective. L'invention concerne le domaine du traitement et du diagnostic du cancer, notamment des carcinomes. Elle porte sur un acide nucléique recombiné et/ou isolé comprenant un promoteur spécifique du tissu ou un fragment fonctionnel de ce dernier, permettant l'expression d'un acide nucléique cible lié fonctionnel audit promoteur ou audit fragment de celui-ci, dans une cellule cancéreuse, ladite expression dans ladite cellule cancéreuse étant sensiblement sélective vis-à-vis des carcinomes.