IMPROVED POLOXAMER AND POLOXAMINE COMPOSITIONS FOR NUCLEIC ACID DELIVERY

The invention features selected polymers such as poloxamer 188 (Pluronic(R) F68), poloxamer 237 (Pluronic(R) F87), poloxamer 401 (Pluronic(R) L121), poloxamer 338 (Pluronic(R) F108), Poloxamer 124 (Pluronic(R) L44), Poloxamer 184 (L-64), and poloxamines (Tetronics(R) 904, 908, 1107, and 90R4) that e...

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Bibliographische Detailangaben
Hauptverfasser:	ROLLAND, ALAIN, COLEMAN, MICHAEL, WANG, JIJUN, NICOL, FRANCOIS, MACLAUGHLIN, FIONA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention features selected polymers such as poloxamer 188 (Pluronic(R) F68), poloxamer 237 (Pluronic(R) F87), poloxamer 401 (Pluronic(R) L121), poloxamer 338 (Pluronic(R) F108), Poloxamer 124 (Pluronic(R) L44), Poloxamer 184 (L-64), and poloxamines (Tetronics(R) 904, 908, 1107, and 90R4) that enhance expression from nucleic acids when administered into an organism, in particular to muscle, and further provides selected poloxamer formulations for delivery of nucleic acids to the liver.