HUMAN CYR61

Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. Polypeptide compositions are also provided. The polypeptide...

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Bibliographische Detailangaben
Hauptverfasser:	GREENSPAN, JEFFREY, A, LAU, LESTER, F, YEUNG, CHO-YAU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES PHYSICS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Beschreibung
Zusammenfassung:	Polynucleotides encoding mammalian ECM signaling molecules affecting the cell adhesion, migration, and proliferation activities characterizing such complex biological processes as angiogenesis, chondrogenesis, and oncogenesis, are provided. Polypeptide compositions are also provided. The polypeptide compositions comprise mammalian ECM signaling molecules, peptide fragments, inhibitory peptides capable of interacting with receptors for ECM signaling molecules, and antibody products recognizing Cyr61. Also provided are methods for producing mammalian ECM signaling molecules, methods for using mammalian ECM signaling molecules to screen for, and/or modulate, conditions and disorders associated with angiogenesis, chondrogenesis, and oncogenesis; and ex vivo methods for using mammalian ECM signaling molecules to prepare blood products. Additionally, modulators, such as peptide modulators, of an ECM signaling molecule activity are provided. Further provided are methods for screening for modulators of a Cyr61 polypeptide-integrin receptor interaction, as well as methods of treating conditions and disorders associated with such an interaction. L'invention porte sur des polynucléotides codant pour les molécules signal de matrices extracellulaires (MEC) de mammifères agissant sur l'adhésion, la migration et la prolifération cellulaires, caractérisant des processus biologiques complexes tels que l'angiogenèse, la chondrogenèse, et l'oncogenèse. Les compositions desdits polynucléotides comportent des ADNs et ARNs comprenant tout ou partie de la séquence de codage d'une molécule signal de MEC, ou ses équivalents biologiques. L'invention porte également: sur des compositions de polypeptide comportant des fragments de peptides de molécules signal de MEC de mammifères, des peptides inhibiteurs pouvant interagir avec les récepteurs desdites molécules et des produits anticorps reconnaissant le Cyr61; sur des méthodes de production de molécules signal de MEC de mammifères; sur des méthodes d'utilisation desdites molécules; sur l'utilisation desdites molécules à des fins de criblage de modulation et d'oncogenèse; sur des méthodes ex vivo d'utilisation desdites molécules pour la préparation de produits sanguins; sur des modulateurs, par exemple peptidiques, de l'activité desdites molécules; sur des méthodes de criblage de l'interaction polypeptide Cyr61/récepteur de l'intégrine; et sur des méthodes de traitement les états et troubles associés à ladite interaction.