METHODS AND MATERIALS RELATING TO PHOSPHOLIPASE-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted phospholipase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human adult ki...

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Bibliographische Detailangaben
Hauptverfasser:	DRMANAC, RADOJE, T, KUO, CHIAUYUN, BOYLE, BRYAN, J, TANG, Y., TOM, ARTERBURN, MATTHEW, C, LIU, CHENGHUA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted phospholipase-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human adult kidney (Invitrogen)(Hyseq clone identification number 11061354 (SEQ ID NO: 1)) and from human mixed tissue (Hyseq identification number 31909463 (SEQ ID NO: 2)). Other aspects of the invention include vectors containing processes for producing novel human secreted phospholipase-like polypeptides, and antibodies specific for such polypeptides. L'invention concerne des polynucléotides, des polypeptides codés par de tels polynucléotides, et des mutants ou des variantes de ceux-ci correspondant à un polypeptide de type pospholipase sécrété par l'organisme humain. Ces polynucléotides contiennent des séquences d'acides nucléiques isolées de bibliothèques d'ADNc provenant du foie adulte humain (Invitrogen) (numéro d'identification de clone Hyseq 11061354 (SEQ ID NO: 1)), et de tissus humains mélangés (numéro d'identification Hyseq 31909463 (SEQ ID NO: 2)). D'autres modes de réalisation de l'invention font intervenir des vecteurs comportant des procédés de fabrication de polypeptides de type phospholipase sécrétés par l'organisme humain, et d'anticorps spécifiques à ces polypeptides.