DINITRILE INTERMEDIATES FOR THE SYNTHESIS OF OMAPATRILAT AND METHODS FOR PRODUCING SAME

Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trails as an anti-hypertensive. Omapatrilat may be synthesized using the S-stereoisomer of a racemic mixture. The ra...

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Hauptverfasser:	BROWN, ROBERT, G, RAFF, DWIGHT, E, RONGIONE, JOSEPH, C
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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