ORGAN TRANSPLANT REJECTION AND ASSOCIATED CONDITIONS

ORGAN TRANSPLANT REJECTION AND ASSOCIATED CONDITIONS

The application discloses markers associated with organ transplant rejection and associated conditions, and in particular provides materials and methods for the diagnosis, prognosis or treatment of chronic rejection of transplanted organ such as heart and kidney. Examples of the markers include ribo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ROSE, MARLENE, LYDIA, LINKE, ADAM, DUNN, MICHAEL, JOHN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The application discloses markers associated with organ transplant rejection and associated conditions, and in particular provides materials and methods for the diagnosis, prognosis or treatment of chronic rejection of transplanted organ such as heart and kidney. Examples of the markers include ribosomal protein L7, beta -transducin, 1-TRAF (also known as TANK) or lysyl-tRNA synthetase, or antibodies against these antigens. La présente invention concerne des marqueurs associés au rejet d'un organe transplanté et les états pathologiques associés, et concerne en particulier des matériaux et des procédés permettant de diagnostiquer, de prévoir ou de traiter le rejet chronique d'un organe transplanté tel qu'un coeur ou un rein. Les marqueurs comprennent par exemple la protéine ribosomale L7, la beta -transducine, la 1-TRAF (appelée également TANK) ou lysyl-ARNt synthase, ou des anticorps contre ces antigènes.